Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

The cystic fibrosis transmembrane conductance regulator (CFTR) attenuates sphingosine-1-phosphate (S1P) signaling in resistance arteries and has emerged as a prominent regulator of myogenic vasoconstriction. This investigation demonstrates that S1P inhibits CFTR activity via adenosine monophosphate-...

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Pubblicato in:PLoS One
Autori principali: Malik, Firhan A., Meissner, Anja, Semenkov, Illya, Molinski, Steven, Pasyk, Stan, Ahmadi, Saumel, Bui, Hai H., Bear, Christine E., Lidington, Darcy, Bolz, Steffen-Sebastian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469317/
https://ncbi.nlm.nih.gov/pubmed/26079370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130313
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