Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.

Structural information is required to define the molecular basis for chloride conduction through CFTR (cystic fibrosis transmembrane conductance regulator). Towards this goal, we expressed MSD2, the second of the two MSDs (membrane-spanning domains) of CFTR, encompassing residues 857-1158 in Sf9 cel...

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Detalhes bibliográficos
Main Authors: Ramjeesingh, Mohabir, Ugwu, Francisca, Li, Canhui, Dhani, Sonja, Huan, Ling Jun, Wang, Yanchun, Bear, Christine E
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223717/
https://ncbi.nlm.nih.gov/pubmed/12892562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030774
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