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Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

The recent cryo-electron microscopy structures of zebrafish and the human cystic fibrosis transmembrane conductance regulator (CFTR) provided unprecedented insights into putative mechanisms underlying gating of its anion channel activity. Interestingly, despite predictions based on channel activity...

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Bibliografiske detaljer
Udgivet i:Cells
Main Authors: Chin, Stephanie, Ramjeesingh, Mohabir, Hung, Maurita, Ereño-Oreba, June, Cui, Hong, Laselva, Onofrio, Julien, Jean-Philippe, Bear, Christine E.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721619/
https://ncbi.nlm.nih.gov/pubmed/31370288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080804
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