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Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

The recent cryo-electron microscopy structures of zebrafish and the human cystic fibrosis transmembrane conductance regulator (CFTR) provided unprecedented insights into putative mechanisms underlying gating of its anion channel activity. Interestingly, despite predictions based on channel activity...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Chin, Stephanie, Ramjeesingh, Mohabir, Hung, Maurita, Ereño-Oreba, June, Cui, Hong, Laselva, Onofrio, Julien, Jean-Philippe, Bear, Christine E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721619/
https://ncbi.nlm.nih.gov/pubmed/31370288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080804
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