Tumor-Suppressor Functions of the TP53 Pathway

Por Aubrey, Brandon J., Strasser, Andreas, Kelly, Gemma L.
Publicado no Cold Spring Harb Perspect Med (2016)

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Por Aubrey, Brandon J, Kelly, Gemma L, Janic, Ana, Herold, Marco J, Strasser, Andreas
Publicado no Cell Death Differ (2018)

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

Por Delbridge, Alex R.D., Pang, Swee Heng Milon, Vandenberg, Cassandra J., Grabow, Stephanie, Aubrey, Brandon J., Tai, Lin, Herold, Marco J., Strasser, Andreas
Publicado no J Exp Med (2016)

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Por Delbridge, Alex RD, Aubrey, Brandon J, Hyland, Craig, Bernardini, Jonathan P, Di Rago, Ladina, Garnier, Jean-Marc, Lessene, Guillaume, Strasser, Andreas, Alexander, Warren S, Grabow, Stephanie
Publicado no Cell Death Dis (2017)

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Por Kelly, Gemma L., Grabow, Stephanie, Glaser, Stefan P., Fitzsimmons, Leah, Aubrey, Brandon J., Okamoto, Toru, Valente, Liz J., Robati, Mikara, Tai, Lin, Fairlie, W. Douglas, Lee, Erinna F., Lindstrom, Mikael S., Wiman, Klas G., Huang, David C.S., Bouillet, Philippe, Rowe, Martin, Rickinson, Alan B., Herold, Marco J., Strasser, Andreas
Publicado em 2014