Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

The transcriptional regulator c-MYC is abnormally overexpressed in many human cancers. Evasion from apoptosis is critical for cancer development, particularly c-MYC-driven cancers. We explored which anti-apoptotic BCL-2 family member (expressed under endogenous regulation) is essential to sustain c-...

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Detalhes bibliográficos
Main Authors: Kelly, Gemma L., Grabow, Stephanie, Glaser, Stefan P., Fitzsimmons, Leah, Aubrey, Brandon J., Okamoto, Toru, Valente, Liz J., Robati, Mikara, Tai, Lin, Fairlie, W. Douglas, Lee, Erinna F., Lindstrom, Mikael S., Wiman, Klas G., Huang, David C.S., Bouillet, Philippe, Rowe, Martin, Rickinson, Alan B., Herold, Marco J., Strasser, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894413/
https://ncbi.nlm.nih.gov/pubmed/24395247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.232009.113
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