Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

The transcriptional regulator c-MYC is abnormally overexpressed in many human cancers. Evasion from apoptosis is critical for cancer development, particularly c-MYC-driven cancers. We explored which anti-apoptotic BCL-2 family member (expressed under endogenous regulation) is essential to sustain c-...

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Main Authors: Kelly, Gemma L., Grabow, Stephanie, Glaser, Stefan P., Fitzsimmons, Leah, Aubrey, Brandon J., Okamoto, Toru, Valente, Liz J., Robati, Mikara, Tai, Lin, Fairlie, W. Douglas, Lee, Erinna F., Lindstrom, Mikael S., Wiman, Klas G., Huang, David C.S., Bouillet, Philippe, Rowe, Martin, Rickinson, Alan B., Herold, Marco J., Strasser, Andreas
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894413/
https://ncbi.nlm.nih.gov/pubmed/24395247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.232009.113
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