A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Like Bcl-2, Mcl-1 is an important survival factor for many cancers, its expression contributing to chemoresistance and disease relapse. However, unlike other prosurvival Bcl-2–like proteins, Mcl-1 stability is acutely regulated. For example, the Bcl-2 homology 3 (BH3)–only protein Noxa, which prefer...

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Main Authors: Lee, Erinna F., Czabotar, Peter E., van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., Puthalakath, Hamsa, Bouillet, Philippe, Colman, Peter M., Huang, David C.S., Fairlie, W. Douglas
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2008
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213596/
https://ncbi.nlm.nih.gov/pubmed/18209102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200708096
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