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Structural insights into the degradation of Mcl-1 induced by BH3 domains
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851040/ https://ncbi.nlm.nih.gov/pubmed/17389404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701297104 |
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