Structural insights into the degradation of Mcl-1 induced by BH3 domains

Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another...

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Bibliographic Details
Main Authors: Czabotar, Peter E., Lee, Erinna F., van Delft, Mark F., Day, Catherine L., Smith, Brian J., Huang, David C. S., Fairlie, W. Douglas, Hinds, Mark G., Colman, Peter M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851040/
https://ncbi.nlm.nih.gov/pubmed/17389404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701297104
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