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How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
The tumour suppressor gene TP53 is mutated in ~50% of human cancers. In addition to its function in tumour suppression, p53 also plays a major role in the response of malignant as well as nontransformed cells to many anticancer therapeutics, particularly those that cause DNA damage. P53 forms a homo...
Tallennettuna:
| Julkaisussa: | Cell Death Differ |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729529/ https://ncbi.nlm.nih.gov/pubmed/29149101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.169 |
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