Natural Products as Topoisomerase II Poisons: Effects of Thymoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα

por Ashley, Rachel E., Osheroff, Neil
Publicado em 2014

Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase

por Ashley, Rachel E., Blower, Tim R., Berger, James M., Osheroff, Neil
Publicado no Biochemistry (2017)

Oxidative transformation of demethoxy- and bisdemethoxycurcumin: Products, mechanism of formation, and poisoning of human topoisomerase IIα

por Gordon, Odaine N., Luis, Paula B., Ashley, Rachel E., Osheroff, Neil, Schneider, Claus
Publicado no Chem Res Toxicol (2015)

Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism

por Lindsey, R. Hunter, Pendleton, MaryJean, Ashley, Rachel E., Mercer, Susan L., Deweese, Joseph E., Osheroff, Neil
Publicado em 2014

Activities of gyrase and topoisomerase IV on positively supercoiled DNA

por Ashley, Rachel E., Dittmore, Andrew, McPherson, Sylvia A., Turnbough, Charles L., Neuman, Keir C., Osheroff, Neil
Publicado no Nucleic Acids Res (2017)

Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance

por Ashley, Rachel E., Lindsey, R. Hunter, McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Publicado no Biochemistry (2017)

Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers

por Dunlap, Norma, Salyard, Tracy L. J., Pathiranage, Anuradha Liyana, Stubblefield, Jeannie, Pitts, Steven L., Ashley, Rachel E., Osheroff, Neil
Publicado no Bioorg Med Chem Lett (2014)