Resultados da pesquisa - brain tumor wt1 treat

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1

IMMU-10. RADIOTHERAPY AND PD-1 BLOCKADE INCREASES TRYPTOPHAN METABOLISM IN BRAIN TUMOR-DRAINING SECONDARY LYMPHOID ORGANS

IMMU-10. RADIOTHERAPY AND PD-1 BLOCKADE INCREASES TRYPTOPHAN METABOLISM IN BRAIN TUMOR-DRAINING SECONDARY LYMPHOID ORGANS

Por Savoor, Rohan, Ladomersky, Erik, Otto-Meyer, Sebastian, Zhai, Lijie, Lauing, Kristen, Lenzen, Alicia, Lukas, Rimas, Wainwright, Derek
Publicado no Neuro Oncol (2018)

“... cells after treatment with brain tumor radiation (RT) and PD-1 mAb (Ladomersky et al., 2018; CCR...”
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2

TNF-Alpha Knockout and Minocycline Treatment Attenuates Blood Brain Barrier Leakage in MPTP-Treated Mice

TNF-Alpha Knockout and Minocycline Treatment Attenuates Blood Brain Barrier Leakage in MPTP-Treated Mice

Por Zhao, Chaohui, Ling, Zaodung, Newman, Mary B., Bhatia, Ankush, Carvey, Paul M.
Publicado em 2007

“...-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Compared with WT mice, TNF-α KO mice treated with MPTP, showed...”
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3

P04.91 ABC-drug efflux transporters at the blood-brain barrier limit the efficacy of treatment against primary and secondary brain tumors

P04.91 ABC-drug efflux transporters at the blood-brain barrier limit the efficacy of treatment against primary and secondary brain tumors

Por van Tellingen, O, de Gooijer, M C, Buil, L C M, Fan, L, de Vries, N A, Kemper, E M, Citirikkaya, C, Beijnen, J H
Publicado no Neuro Oncol (2018)

“... models), the levels further increase when the same tumors grow in ABCG2/ABCB1 KO mice and/or in WT mice...”
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4

CADD-42. EFFICACY OF MUTANT INTERLEUKIN-13 ALPHA-2 RECEPTOR–TARGETED LIPOSOMAL DOXORUBICIN IN THE INTRACRANIAL BRAIN TUMOR MODEL

CADD-42. EFFICACY OF MUTANT INTERLEUKIN-13 ALPHA-2 RECEPTOR–TARGETED LIPOSOMAL DOXORUBICIN IN THE INTRACRANIAL BRAIN TUMOR MODEL

Por Nesterova, Darya, Madhankumar, Achuthamangalam, Mrowczynski, Oliver, Sue Webb, Becky, Connor, James
Publicado no Neuro Oncol (2018)

“... treated with unconjugated liposomes. WT-IL13, however, also binds to the shared IL-13/IL-4 receptor α(1...”
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5

PDTM-15. IDENTIFICATION AND CHARACTERIZATION OF WILMS’ TUMOR PROTEIN IN PEDIATRIC MIDLINE GLIOMAS

PDTM-15. IDENTIFICATION AND CHARACTERIZATION OF WILMS’ TUMOR PROTEIN IN PEDIATRIC MIDLINE GLIOMAS

Por Lee, Sulgi, Kambhampati, Madhuri, Yadavilli, Sridevi, Gordish-Dressman, Heather, Santi, Mariarita, Cruz, Conrad, Packer, Roger, Almira-Suaurez, Isabel, Hwang, Eugene, Nazarian, Javad
Publicado no Neuro Oncol (2018)

“...’ tumor protein (WT1) has been ranked number 1 cancer immunotherapy target by National Cancer Institute...”
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6

P04.07 Relapse in a paucisymptomatic form of multiple sclerosis in a patient treated with nivolumab

P04.07 Relapse in a paucisymptomatic form of multiple sclerosis in a patient treated with nivolumab

Por Gómez Vicente, L., Rubio Viqueira, B., Jimenez de las Peñas, M., Garcia Cobos, R., Pardo Moreno, J., Arroyo Gonzalez, R.
Publicado no Neuro Oncol (2016)

“...-CTLA4, anti-PDL1 and antiPDL2 antibodies, is changing the way to treat patients with cancer. Nivolumab...”
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7

Session 1

Publicado em 2014

“... in the Proteogenomic Analysis of 105 TCGA Breast Tumors Karl R. Clauser(1), David Fenyö(2), Kelly V. Ruggles(2...”
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8

Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis

Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis

Por Weiss, Sarah, Darvishian, Farbod, Tadepalli, Jyothi, Shapiro, Richard, Golfinos, John, Pavlick, Anna, Polsky, David, Kirchhoff, Tomas, Osman, Iman
Publicado no BMC Cancer (2015)

“.... The patient’s resected brain tumor is BRAF V600E mutated, NRAS wild type (WT), and TERT C250T mutated...”
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9

DIPG-30. ISOFORM SPECIFIC OVEREXPRESSION OF WILMS’ TUMOR PROTEIN IN DIFFUSE INTRINSIC PONTINE GLIOMAS

DIPG-30. ISOFORM SPECIFIC OVEREXPRESSION OF WILMS’ TUMOR PROTEIN IN DIFFUSE INTRINSIC PONTINE GLIOMAS

Por Lee, Sulgi, Kambhampati, Madhuri, Yadavilli, Sridevi, Gordish-Dressman, Heather, Gaonkar, Krutika, Raman, Pichai, Cruz, Conrad, Packer, Roger, Almira-Suarez, M Isabel, Becher, Oren, Resnick, Adam, Mueller, Sabine, Hwang, Eugene, Nazarian, Javad
Publicado no Neuro Oncol (2019)

“..., RNA-seq analysis of DIPG tumors (n=23) revealed specific transcriptome expression of WT1 transcript...”
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10

Gallium Nanoparticle-Mediated Reduction of Brain Specific Serine Protease-4 in an Experimental Metastatic Cancer Model

Gallium Nanoparticle-Mediated Reduction of Brain Specific Serine Protease-4 in an Experimental Metastatic Cancer Model

Por Moustafa, Enas M, Mohamed, Marwa Abdelhameed, Thabet, Noura M
Publicado no Asian Pac J Cancer Prev (2017)

“... mg/kg.b.wt.; for 6 weeks) to induce HCC and were treated with Ga nanoparticles (GaNPs...”
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11

In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways

In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways

Por Daphu, Inderjit, Horn, Sindre, Stieber, Daniel, Varughese, Jobin K., Spriet, Endy, Dale, Hege Avsnes, Skaftnesmo, Kai Ove, Bjerkvig, Rolf, Thorsen, Frits
Publicado em 2014

“..., we treated two melanoma brain metastasis cell lines, H1_DL2, harboring a BRAF(V600E) mutation...”
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12

A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier

A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier

Por Kim, Do-Geun, Bynoe, Margaret S.
Publicado no J Clin Invest (2016)

“... circulation. It maintains brain homeostasis and is a hurdle for drug delivery to the CNS to treat...”
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13

P01.03 FUNCTIONAL CHARACTERISATION OF THE ISOCITRATE DEHYDROGENASE 1 (IDH 1) R132H MUTATION IN GLIOMAS

P01.03 FUNCTIONAL CHARACTERISATION OF THE ISOCITRATE DEHYDROGENASE 1 (IDH 1) R132H MUTATION IN GLIOMAS

Por Biedermann, J., El-Ardat, K.Abou, Conde, M., Wiedemuth, R., Peitzsch, M., Eisenhofer, G., Kunz-Schughart, L., Temme, A., Schröck, E., Klink, B.
Publicado em 2014

“... level in comparison with IDH1 wt cells treated with 2HG. Based on these profiles we aim to investigate...”
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14

Adenosine A(1) Receptors and Microglial Cells Mediate CX3CL1-Induced Protection of Hippocampal Neurons Against Glu-Induced Death

Adenosine A(1) Receptors and Microglial Cells Mediate CX3CL1-Induced Protection of Hippocampal Neurons Against Glu-Induced Death

Por Lauro, Clotilde, Cipriani, Raffaela, Catalano, Myriam, Trettel, Flavia, Chece, Giuseppina, Brusadin, Valentina, Antonilli, Letizia, van Rooijen, Nico, Eusebi, Fabrizio, Fredholm, Bertil B, Limatola, Cristina
Publicado em 2010

“... the release of cytokines from microglia, reducing the level of tumor necrosis factor-α, interleukin-1-β...”
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15

Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity

Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity

Por Ativie, Frank, Komorowska, Joanna A., Beins, Eva, Albayram, Önder, Zimmer, Till, Zimmer, Andreas, Tejera, Dario, Heneka, Michael, Bilkei-Gorzo, Andras
Publicado no Front Mol Neurosci (2018)

“... microglia from saline-treated GABA/CB1(−/−) mice resembled those of LPS-treated WT mice: enhanced density...”
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16

Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β

Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β

Por Braun, Theodore P, Grossberg, Aaron J, Veleva-Rotse, Biliana O, Maxson, Julia E, Szumowski, Marek, Barnes, Anthony P, Marks, Daniel L
Publicado em 2012

“... and LMA in WT mice. MyD88KO mice were protected from these changes in response to i.c.v. IL-1β despite...”
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17

IMMU-22. COMBINATION IMMUNOTHERAPY WITH IDO1 INHIBITION ENHANCES TREATMENT EFFICACY IN MULTIPLE MODELS OF GLIOBLASTOMA MODEL

IMMU-22. COMBINATION IMMUNOTHERAPY WITH IDO1 INHIBITION ENHANCES TREATMENT EFFICACY IN MULTIPLE MODELS OF GLIOBLASTOMA MODEL

Por Ladomersky, Erik, Zhai, Lijie, Lauing, Kristen, Wu, Meijing, James, C David, Stupp, Roger, Wainwright, Derek
Publicado no Neuro Oncol (2017)

“.... Results from the analysis of WT and IDO1(-/-) mice with intracranial tumor indicate that in the presence...”
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18

Qualitative and Quantitative Analysis of IDH1 Mutation in Progressive Gliomas by Allele-Specific qPCR and Western Blot Analysis

Qualitative and Quantitative Analysis of IDH1 Mutation in Progressive Gliomas by Allele-Specific qPCR and Western Blot Analysis

Por Perrech, Moritz, Dreher, Lena, Röhn, Gabriele, Stavrinou, Pantelis, Krischek, Boris, Toliat, Mohammad, Goldbrunner, Roland, Timmer, Marco
Publicado no Technol Cancer Res Treat (2019)

“... with specific primers for IDH1 mutation and –wt; protein expression was verified by Western Blot analysis...”
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19

Interação B1R/TLR4 como mecanismo de resposta inflamatória e sua implicação na barreira hematoencefálica em modelo de glioblastoma /

Interação B1R/TLR4 como mecanismo de resposta inflamatória e sua implicação na barreira hematoencefálica em modelo de glioblastoma /

Por Batista, Carolina, Mendes, Fabio de Almeida., Silva, Joice Stipursky., Pesquero, João Bosco., Universidade Federal do Rio de Janeiro.
Publicado em 2024.

“... WT e nocautes para B1R ou TLR4 observamos que a ausência de B1R modifica a resposta de TLR4 e vice...”
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20

A chimeric adenovirus with an Ad 3 fiber knob modification augments glioma virotherapy

A chimeric adenovirus with an Ad 3 fiber knob modification augments glioma virotherapy

Por Nandi, Suvobroto, Ulasov, Ilya V., Rolle, Cleo E., Han, Yu, Lesniak, Maciej S.
Publicado em 2009

“.... METHODS: To increase the infectivity and replication of oncolytic vectors in malignant brain tumors, we...”
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