P04.91 ABC-drug efflux transporters at the blood-brain barrier limit the efficacy of treatment against primary and secondary brain tumors

BACKGROUND: ABCB1 (P-glycoprotein; Pgp) and ABCG2 (Breast Cancer Resistance Protein; BCRP) are drug efflux transporters that are abundantly expressed at the blood-brain barrier (BBB). They limit the brain penetration of numerous compounds including many anticancer agents and protect the brain from d...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuro Oncol
Egile Nagusiak: van Tellingen, O, de Gooijer, M C, Buil, L C M, Fan, L, de Vries, N A, Kemper, E M, Citirikkaya, C, Beijnen, J H
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2018
Gaiak:
Poster Presentations
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144727/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.325
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