DDRE-32. ABC TRANSPORTERS RESTRICT THE BRAIN PENETRATION AND INTRACRANIAL EFFICACY OF ANTICANCER AGENTS EVEN WHEN BLOOD-BRAIN BARRIER INTEGRITY IS LOST

The impact of the blood-brain barrier (BBB) in brain tumors on the efficacy of anticancer drug therapy is controversial. In primary as well as metastatic brain tumors, the BBB is often disrupted. Yet, many intracranial cancers respond poorly to systemic therapies. We characterized the integrity of t...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: de Gooijer, Mark C, Kemper, E Marleen, Buil, Levi C M, Çitirikkaya, Ceren H, Buckle, Tessa, Beijnen, Jos H, van Tellingen, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Discovery, Drug Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651270/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.277
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