DDRE-01. ACQUIRED AND INTRINSIC RESISTANCE TO VEMURAFENIB IN BRAF(V600E)-DRIVEN MELANOMA BRAIN METASTASES

BRAF (V600)-mutated melanoma brain metastases (MBMs) are responsive to BRAF inhibitors, but clinical responses are less durable than those of extracranial metastases. We studied the impact of the drug efflux proteins P-glycoprotein (P-gp; ABCB1) and breast cancer resistance protein (BCRP; ABCG2) at...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: de Gooijer, Mark C, Zhang, Ping, Buil, Levi C M, Freriks, Stephan, Li, Gang, Beijnen, Jos H, van Tellingen, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Discovery, Drug Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651742/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.246
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