ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost

The impact of a compromised blood-brain barrier (BBB) on the drug treatment of intracranial tumors remains controversial. We characterize the BBB integrity in several intracranial tumor models using magnetic resonance imaging, fluorescent dyes, and autoradiography and determine the distribution and...

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Publicado en:Cell Rep Med
Main Authors: de Gooijer, Mark C., Kemper, E. Marleen, Buil, Levi C.M., Çitirikkaya, Ceren H., Buckle, Tessa, Beijnen, Jos H., van Tellingen, Olaf
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817868/
https://ncbi.nlm.nih.gov/pubmed/33521698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100184
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