Resultados da pesquisa - Comb Chem High Throughput Screen

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Immobilized OBOC combinatorial bead array to facilitate multiplicative screening

Por Xiao, Wenwu, Bononi, Fernanda C., Townsend, Jared, Li, Yuanpei, Liu, Ruiwu, Lam, Kit S.
Publicado no Comb Chem High Throughput Screen (2013)

“...One-bead-one-compound (OBOC) combinatorial library screening has been broadly utilized for the last...”
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22

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Machine Learning for In Silico Virtual Screening and Chemical Genomics: New Strategies

Por Vert, Jean-Philippe, Jacob, Laurent
Publicado em 2008

“... framework that implicitly embeds the data of interest, respectively proteins and small molecules, in high...”
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An Image-Based Biosensor Assay Strategy to Screen for Modulators of the microRNA 21 Biogenesis Pathway

Por Shum, David, Bhinder, Bhavneet, Radu, Constantin, Calder, Paul, Ramirez, Christina N., Djaballah, Hakim
Publicado em 2012

“...-based assay strategy to screen for such modulators. Here, we describe its successful implementation...”
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A 1536-well Fluorescence Polarization Assay to Screen for Modulators of the MUSASHI Family of RNA-Binding Proteins

Por Minuesa, Gerard, Antczak, Christophe, Shum, David, Radu, Constantin, Bhinder, Bhavneet, Li, Yueming, Djaballah, Hakim, Kharas, Michael G.
Publicado em 2014

“... developed a fluorescence polarization (FP) assay and optimized it for high throughput screening (HTS) in a...”
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25

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Antibodies against G-protein coupled receptors: novel uses in screening and drug development

Por Gupta, Achla, Heimann, Andrea S., Gomes, Ivone, Devi, Lakshmi A.
Publicado em 2008

“... screening of targets for drug discovery and testing. In addition, the introduction of antibodies...”
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Synthesis, Screening, and Sequencing of Cysteine-Rich One-Bead One-Compound Peptide Libraries

Por Juskowiak, Gary L., McGee, Christopher J., Greaves, John, Van Vranken, David L.
Publicado em 2008

“... OBOC libraries to be used in high-throughput discovery of cysteine-rich peptides for protein tagging...”
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Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

Por Rappaz, Benjamin, Breton, Billy, Shaffer, Etienne, Turcatti, Gerardo
Publicado em 2014

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Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS

Por Choi, Yongsoo, van Breemen, Richard B.
Publicado em 2008

“...A high throughput screening assay for the identification of ligands to pharmacologically...”
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29

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Chemical & RNAi screening at MSKCC: a collaborative platform to discover & repurpose drugs to fight disease

Por Bhinder, Bhavneet, Antczak, Christophe, Shum, David, Radu, Constantin, Mahida, Jeni P., Liu-Sullivan, Nancy, Ibáñez, Glorymar, Raja, Balajee Somalinga, Calder, Paul A., Djaballah, Hakim
Publicado em 2014

“...-of-the-art High-throughput Screening Core Facility (HTSCF) equipped with modern robotics and custom-built...”
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A High Content Assay to Assess Cellular Fitness

Por Antczak, Christophe, Mahida, Jeni P., Singh, Chanpreet, Calder, Paul A., Djaballah, Hakim
Publicado em 2014

“... and RNAi screening. In summary, we report on a high content assay method to assess cellular overall fitness...”
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31

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Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance

Por McKim, James M
Publicado em 2010

“... allow compounds with high risk profiles to be deprioritized, while those that possess the requisite drug...”
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32

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Modulators of the microRNA biogenesis pathway via arrayed lentiviral enabled RNAi screening for drug and biomarker discovery

Por Shum, David, Bhinder, Bhavneet, Djaballah, Hakim
Publicado em 2013

“.... For this purpose, we performed an RNAi screen aimed at identifying genes involved in their biogenesis pathway...”
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A simple method for analyzing actives in random RNAi screens: introducing the “H Score” for hit nomination & gene prioritization

Por Bhinder, Bhavneet, Djaballah, Hakim
Publicado em 2012

“...Due to the numerous challenges in hit identification from random RNAi screening, we have examined...”
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Comparative analysis of RNAi screening technologies at genome-scale reveals an inherent processing inefficiency of the plasmid-based shRNA hairpin

Por Bhinder, Bhavneet, Shum, David, Djaballah, Hakim
Publicado em 2014

“...RNAi screening in combination with the genome-sequencing projects would constitute the Holy Grail...”
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Systematic analysis of RNAi reports identifies dismal commonality at gene-level & reveals an unprecedented enrichment in pooled shRNA screens

Por Bhinder, Bhavneet, Djaballah, Hakim
Publicado em 2013

“... in the shRNA ones. Furthermore, EIF5B emerges as the most common hit only in the shRNA screens. A highly...”
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High-Content Profiling of Cell Responsiveness to Graded Substrates Based on Combinatorially Variant Polymers

Por Liu, Er, Treiser, Matthew D., Patel, Hiral, Sung, Hak-Joon, Roskov, Kristen E., Kohn, Joachim, Becker, Matthew L., Moghe, Prabhas V.
Publicado em 2009

“...We have developed a novel approach combining high information and high throughput analysis...”
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Development of Selective High Affinity Antagonists, Agonists, and Radioligands for the P2Y(1) Receptor

Por Houston, Dayle, Costanzi, Stefano, Jacobson, Kenneth A., Harden, T. Kendall
Publicado em 2008

“... role in platelet aggregation. We have designed a set of highly selective and diverse pharmacological...”
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Phage-displayed combinatorial peptide libraries in fusion to β-lactamase as reporter for an accelerated clone screening: Potential uses of selected enzyme-linked affinity reagents in downstream...

Por Shukla, Girja S., Krag, David N.
Publicado em 2010

“... for a high throughput platform. Target-specific β-lactamase-linked affinity reagents selected...”
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Development and Validation of a High-density Fluorescence Polarization-based Assay for the Trypanosoma RNA Triphosphatase TbCet1

Por Antczak, Christophe, Shum, David, Radu, Constantin, Seshan, Venkatraman E., Djaballah, Hakim
Publicado em 2009

“... and discuss our findings and their importance for the discovery of novel drugs by high-throughput screening....”
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Fabricating Gradient Hydrogel Scaffolds for 3D Cell Culture

Por Chatterjee, Kaushik, Young, Marian F., Simon, Carl G.
Publicado em 2011

“.... Combinatorial and high-throughput (CHT) methods can be used to systematically screen tissue scaffolds...”
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