Resultados da pesquisa - (( j small compound cases new ) OR ((( j (nal OR nayla) clamp a non ) OR ( j parr c i non ))))*

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Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Por Hall, Jason C., Marlow, Laura A., Mathias, Adam C., Dawson, Louis K., Durham, William F., Meshaw, Kenneth A., Mullin, Robert J., Synnott, Aidan J., Small, Daniel L., Krishna, Murli, von Hoff, Daniel, Schüler, Julia, Hart, Steven N., Couch, Fergus J., Colon-Otero, Gerardo, Copland, John A.
Publicado no J Transl Med (2016)

“...BACKGROUND: Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for <1...”
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Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds

Por Bergen, Dylan J. M., Kague, Erika, Hammond, Chrissy L.
Publicado no Front Endocrinol (Lausanne) (2019)

“... and that simultaneously can be used as a compound testing platform. Zebrafish, a small teleost fish, are increasingly used...”
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The Development of New Therapies for Human Herpesvirus 6

Por Prichard, Mark N., Whitley, Richard J.
Publicado no Curr Opin Virol (2014)

“... for the treatment of these infections, although small studies and individual case reports have reported intermittent...”
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Harnessing Social Networks along with Consumer-Driven Electronic Communication Technologies to Identify and Engage Members of 'Hard-to-Reach' Populations: A Methodological Case Report

Por Rock, Melanie J
Publicado em 2010

“... in ethnographic case study research with a 'hard-to-reach' population. METHODS: To identify and engage a small yet...”
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Cultural adaptation, compounding vulnerabilities and conjunctures in Norse Greenland

Por Dugmore, Andrew J., McGovern, Thomas H., Vésteinsson, Orri, Arneborg, Jette, Streeter, Richard, Keller, Christian
Publicado em 2012

“... their traditional ecological knowledge base, and a case of being too specialized, too small, and too isolated...”
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Natural Products as Sources of New Drugs over the 30 Years from 1981 to 2010()

Por Newman, David J., Cragg, Gordon M.
Publicado em 2012

“... the original primary divisions, and have added a new designation “natural product botanical” or “NB” to cover...”
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Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

Por Cherry, Jonathan J, Osman, Erkan Y, Evans, Matthew C, Choi, Sungwoon, Xing, Xuechao, Cuny, Gregory D, Glicksman, Marcie A, Lorson, Christian L, Androphy, Elliot J
Publicado em 2013

“... copies of the SMN1 gene. SMN2 is a nearly identical copy of SMN1, which expresses much less functional...”
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Cefuroxime, a New Cephalosporin Antibiotic: Activity In Vitro

Por O'Callaghan, Cynthia H., Sykes, R. B., Griffiths, A., Thornton, J. E.
Publicado em 1976

“...Cefuroxime is a new broad-spectrum cephalosporin antibiotic with increased stability to β...”
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Peptide-Based Catalysts Reach the Outer Sphere through Remote Desymmetrization and Atroposelectivity

Por Metrano, Anthony J., Miller, Scott J.
Publicado no Acc Chem Res (2018)

“... Å and from one another by nearly 1 nm. Various hydroxyl group functionalizations and electrophilic...”
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Predicting QRS and PR interval prolongations in humans using nonclinical data

Por Bergenholm, L, Parkinson, J, Mettetal, J, Evans, N D, Chappell, M J, Collins, T
Publicado no Br J Pharmacol (2017)

“... cardiovascular safety risk for non–arrhythmic drugs, this study provides a means of predicting human QRS/PR...”
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Incorporating Virtual Reactions into a Logic-based Ligand-based Virtual Screening Method to Discover New Leads

Por Reynolds, Christopher R, Muggleton, Stephen H, Sternberg, Michael J E
Publicado no Mol Inform (2015)

“... a target. These databases can only represent a small fraction of chemical space, and this paper...”
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Identification of small molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

Por Wahome, Paul G., Bai, Yan, Neal, Lori M., Robertus, Jon D., Mantis, Nicholas J.
Publicado em 2010

“... to identify small-molecule inhibitors of these toxins that could serve as lead compounds for potential...”
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Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

Por Boehm, Markus, Hepworth, David, Loria, Paula M., Norquay, Lisa D., Filipski, Kevin J., Chin, Janice E., Cameron, Kimberly O., Brenner, Martin, Bonnette, Peter, Cabral, Shawn, Conn, Edward, Ebner, David C., Gautreau, Denise, Hadcock, John, Lee, Esther C. Y., Mathiowetz, Alan M., Morin, Michelle, Rogers, Lucy, Smith, Aaron, VanVolkenburg, Maria, Carpino, Philip A.
Publicado em 2013

“... of oGPCRs resulted in the discovery of the first reported small molecule agonists for GPR39, a receptor...”
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Structure-based Design of Novel Small-Molecule Inhibitors of Plasmodium falciparum

Por Kortagere, Sandhya, Welsh, William J., Morrisey, Joanne M., Daly, Thomas, Ejigiri, Ijeoma, Sinnis, Photini, Vaidya, Akhil B., Bergman, Lawrence W.
Publicado em 2010

“... each year. The need to design a new generation of antimalarial drugs that can combat the most drug...”
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Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development

Por van Westen, Gerard J. P., Wegner, Jörg K., Geluykens, Peggy, Kwanten, Leen, Vereycken, Inge, Peeters, Anik, IJzerman, Adriaan P., van Vlijmen, Herman W. T., Bender, Andreas
Publicado em 2011

“..., the targets in this case being a set of 14 HIV Reverse Transcriptase (RT) mutants. We validated our model...”
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Hydrogen bonding in bulk heterojunction solar cells: A case study

Por Xiao, Zeyun, Sun, Kuan, Subbiah, Jegadesan, Ji, Shaomin, Jones, David J., Wong, Wallace W. H.
Publicado em 2014

“.... The amide containing small molecule can form intermolecular hydrogen bonding between N-H…O = C of the amide...”
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Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV(+) cells

Por Yuan, C-H, Filippova, M, Krstenansky, J L, Duerksen-Hughes, P J
Publicado no Cell Death Dis (2016)

“...High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer, as well...”
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Chemically Aware Model Builder (camb): an R package for property and bioactivity modelling of small molecules

Por Murrell, Daniel S, Cortes-Ciriano, Isidro, van Westen, Gerard J P, Stott, Ian P, Bender, Andreas, Malliavin, Thérèse E, Glen, Robert C
Publicado no J Cheminform (2015)

“... of 905 one-dimensional and 14 fingerprint type descriptors for small molecules, 8 types of amino acid...”
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KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro

Por Zeeman, Anne-Marie, van Amsterdam, Sandra M., McNamara, Case W., Voorberg-van der Wel, Annemarie, Klooster, Els J., van den Berg, Alexander, Remarque, Edmond J., Plouffe, David M., van Gemert, Geert-Jan, Luty, Adrian, Sauerwein, Robert, Gagaring, Kerstin, Borboa, Rachel, Chen, Zhong, Kuhen, Kelli, Glynne, Richard J., Chatterjee, Arnab K., Nagle, Advait, Roland, Jason, Winzeler, Elizabeth A., Leroy, Didier, Campo, Brice, Diagana, Thierry T., Yeung, Bryan K. S., Thomas, Alan W., Kocken, Clemens H. M.
Publicado em 2014

“...) will be essential. A new compound with potential radical cure activity was identified using a low-throughput assay...”
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Lipid droplet-associated proteins (LDAPs) are involved in the compartmentalization of lipophilic compounds in plant cells

Por Gidda, Satinder K, Watt, Samantha C, Collins-Silva, Jillian, Kilaru, Aruna, Arondel, Vincent, Yurchenko, Olga, Horn, Patrick J, James, Christopher N, Shintani, David, Ohlrogge, John B, Chapman, Kent D, Mullen, Robert T, Dyer, John M
Publicado em 2013

“... in the specialized case of oleosins, which are associated with seed lipid droplets. Recently, we identified a new...”
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