Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development

In quite a few diseases, drug resistance due to target variability poses a serious problem in pharmacotherapy. This is certainly true for HIV, and hence, it is often unknown which drug is best to use or to develop against an individual HIV strain. In this work we applied ‘proteochemometric’ modeling...

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Hlavní autoři: van Westen, Gerard J. P., Wegner, Jörg K., Geluykens, Peggy, Kwanten, Leen, Vereycken, Inge, Peeters, Anik, IJzerman, Adriaan P., van Vlijmen, Herman W. T., Bender, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223189/
https://ncbi.nlm.nih.gov/pubmed/22132107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027518
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