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Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data.

Infection with HIV cannot currently be cured; however it can be controlled by combination treatment with multiple anti-retroviral drugs. Given different viral genotypes for virtually each individual patient, the question now arises which drug combination to use to achieve effective treatment. With t...

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Main Authors: Gerard J P van Westen, Alwin Hendriks, Jörg K Wegner, Adriaan P Ijzerman, Herman W T van Vlijmen, Andreas Bender
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Acceso en liña:http://europepmc.org/articles/PMC3578754?pdf=render
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