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1
“... delay and clonogenic cell survival during repeated drug treatment. A slow rate of resistance development...”
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2
Por Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Maxim I. Sorokin, Maxim I. Sorokin, Maxim I. Sorokin, Anna A. Emelianova, Nikolay M. Borisov, Nikolay M. Borisov, Denis V. Kuzmin, Pieter Borger, Andrew V. Garazha, Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin
Publicado em 2019-01-01
Assuntos:
“...DNA mutation...”Publicado em 2019-01-01
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3
Por Bhattacharya, Sudin, Shoda, Lisl K.M., Zhang, Qiang, Woods, Courtney G., Howell, Brett A., Siler, Scott Q., Woodhead, Jeffrey L., Yang, Yuching, McMullen, Patrick, Watkins, Paul B., Andersen, Melvin E.
Publicado em 2012
“... involves development of a spatial, multicellular “virtual tissue” model of the liver lobule that combines...”Publicado em 2012
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4
“... propose a multiscale modeling approach—from in vitro to preclinical and clinical studies—to develop cell...”
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5
“..., the present paper offers a review of recent developments in the CHARMM additive force field, one of the most...”
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6
Por Hoffman-Luca, C. Gianna, Yang, Chao-Yie, Lu, Jianfeng, Ziazadeh, Daniel, McEachern, Donna, Debussche, Laurent, Wang, Shaomeng
Publicado no PLoS One (2015)
“.... Computational modeling suggested that a p53 tetramer containing two wild-type p53 molecules and two C176F...”Publicado no PLoS One (2015)
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7
Por Theron, Grant, Peter, Jonny, Richardson, Marty, Warren, Rob, Dheda, Keertan, Steingart, Karen R
Publicado no Cochrane Database Syst Rev (2016)
“...BACKGROUND: Genotype® MTBDRsl (MTBDRsl) is a rapid DNA‐based test for detecting specific mutations...”Publicado no Cochrane Database Syst Rev (2016)
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8
“...Cytotoxic drug resistance developing after chemotherapy is thought to be the main cause...”
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9
Por Khan Suleiman A, Faisal Ali, Mpindi John, Parkkinen Juuso A, Kalliokoski Tuomo, Poso Antti, Kallioniemi Olli P, Wennerberg Krister, Kaski Samuel
Publicado em 2012-05-01
“... elicited by specific chemical features. As a step towards creating such computational links we developed a...”Publicado em 2012-05-01
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10
“... of deoxyribonucleic acid (DNA) was used. This preparation is a drug known as a mixture of peptides...”
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11
Por Khan, Suleiman A, Faisal, Ali, Mpindi, John Patrick, Parkkinen, Juuso A, Kalliokoski, Tuomo, Poso, Antti, Kallioniemi, Olli P, Wennerberg, Krister, Kaski, Samuel
Publicado em 2012
“... to build better models of drug effects, including unanticipated types of molecular properties having strong...”Publicado em 2012
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12
“...The Drosophila DNA topoisomerase type I mutant allele, top1(JS) is an effective general seizure...”
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13
Por de Boer, Richard, Smith, Ruben L., De Vos, Winnok H., Manders, Erik M. M., Brul, Stanley, van der Spek, Hans
Publicado no PLoS One (2015)
“...-analogue type compounds on the functioning of the mitochondrial DNA polymerase. For detailed investigation...”Publicado no PLoS One (2015)
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14
“... that topoisomerase-mediated DNA damage is amenable to such repair. Using a bacteriophage T4 model system, we have...”
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15
“... to understand the evolutionary dynamics that allow tumors to develop chemoresistance, a comprehensive...”
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16
“... dynamics that allow tumors to develop chemoresistance, a comprehensive quantitative model must be used...”
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17
“... mouse leukemia L1210/0 as a reference wild-type cell line, and cisplatin-resistant subclones have been...”
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18
Por Alekseeva, Ludmila A., Mironova, Nadezhda L., Brenner, Evgenyi V., Kurilshikov, Alexander M., Patutina, Olga A., Zenkova, Marina A.
Publicado no PLoS One (2017)
“... and hepatocellular carcinoma A1 tumour models, we have shown the antimetastatic activity of bovine DNase I, which...”Publicado no PLoS One (2017)
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19
Por Jang, Jiho, Yoo, Jeong-Eun, Lee, Jeong-Ah, Lee, Dongjin R., Kim, Ji Young, Huh, Yong Jun, Kim, Dae-Sung, Park, Chul-Yong, Hwang, Dong-Youn, Kim, Han-Soo, Kang, Hoon-Chul, Kim, Dong-Wook
Publicado em 2012
“... with incurable diseases is a promising approach for studying disease mechanisms and drug screening...”Publicado em 2012
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20
Por Rubin Donald H, Hodge Thomas W, Sheng Jinsong, Li Guangyu, Murray James L, Friedrich Brian M, O'Brien William A, Ferguson Monique R
Publicado em 2011-05-01
“..., our data support a model whereby ADAM10 is cleaved by ADAM15 and γ-secretase and that the ADAM10...”Publicado em 2011-05-01
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