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61
“... diversity, and multiple uses of active compounds to treat various diseases. Attention has been directed...”
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62
Por Mendes, Vanessa I. S., Bartholomeusz, Geoffrey A., Ayres, Mary, Gandhi, Varsha, Salvador, Jorge A. R.
Publicado no Eur J Med Chem (2016)
“...-small cell lung cancer (NSCLC) cell lines using 2D and 3D culture models. Compound 17, bearing a cleaved...”Publicado no Eur J Med Chem (2016)
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63
Por Siwo, Geoffrey H., Smith, Roger S., Tan, Asako, Button-Simons, Katrina A., Checkley, Lisa A., Ferdig, Michael T.
Publicado no BMC Genomics (2015)
“... compounds. To determine the target biological pathways for each small molecule, we developed a novel...”Publicado no BMC Genomics (2015)
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64
“... site that can be used to rationally optimize such compounds. We also propose a set of new potential DNA...”
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65
“... provides a comprehensive look at possible targets for small molecule intervention as well as some new...”
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66
Por Katt, William P., Blobel, Nicolas J., Komarova, Svetlana, Antonyak, Marc A., Nakano, Ichiro, Cerione, Richard A.
Publicado no Oncotarget (2018)
“... represents the lead compound for a new class of small molecules that promote the toxicity of cancer cells...”Publicado no Oncotarget (2018)
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67
Por Baig, M. H., Ahmad, K., Hasan, Q., Khan, M. K. A., Rao, N. S., Kamal, M. A., Choi, I.
Publicado no Evid Based Complement Alternat Med (2015)
“..., and the search for a new and effective natural GCGR antagonist is an important area for the treatment of type 2...”Publicado no Evid Based Complement Alternat Med (2015)
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68
Por Effenberger, Kerstin A., Urabe, Veronica K., Jurica, Melissa S.
Publicado no Wiley Interdiscip Rev RNA (2016)
“...1 inhibitors stand out as a great example of what can be accomplished with small molecule tools...”Publicado no Wiley Interdiscip Rev RNA (2016)
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69
70
“... by the spontaneous flow of Na(+) ions into the cellular phase. Dependent on (a) which compound was used, (b) its...”
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71
Por Huertas, D, Soler, M, Moreto, J, Villanueva, A, Martinez, A, Vidal, A, Charlton, M, Moffat, D, Patel, S, McDermott, J, Owen, J, Brotherton, D, Krige, D, Cuthill, S, Esteller, M
Publicado em 2012
“... kinases can be blocked by small drugs and several clinical trials are underway with these agents...”Publicado em 2012
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72
Por Guzmán, Esther A., Johnson, Jacob D., Linley, Patricia A., Gunasekera, Sarath E., Wright, Amy E.
Publicado em 2010
“... resistance to apoptosis. Small molecules that can restore sensitivity to apoptosis or reduce metastasis would...”Publicado em 2010
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73
Por Carlesso, Antonio, Chintha, Chetan, Gorman, Adrienne M., Samali, Afshin, Eriksson, Leif A.
Publicado no Sci Rep (2019)
“... prompted interest in exploring structure-based drug design as a strategy to develop new covalently binding...”Publicado no Sci Rep (2019)
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74
“... inhibition of ENTPD5. We performed a high-throughput screen (HTS) of 21,120 compounds to identify small...”
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75
Por Genthe, Jamie R., Min, Jaeki, Farmer, Dana M., Shelat, Anang A., Grenet, Jose A., Lin, Wenwei, Finkelstein, David, Vrijens, Karen, Chen, Taosheng, Guy, R. Kiplin, Clements, Wilson K., Roussel, Martine F.
Publicado no ACS Chem Biol (2017)
“...Here we describe three new small-molecule activators of BMP signaling found by high throughput...”Publicado no ACS Chem Biol (2017)
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76
Por S. A. Demchenko, Yu. A. Fedchenkova, L. S. Bobkova, L. P. Artemchuk, A. M. Demchenko
Publicado em 2019-02-01
“...-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta [cd]azulene derivatives.
Results and discussion. To determine...”Publicado em 2019-02-01
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77
“... small priming quantity of acetyl CoA served to generate acrylyl CoA, which, by hydration, generated beta...”
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78
Por Zhang, Zhengdong, Burch, Paula E., Cooney, Austin J., Lanz, Rainer B., Pereira, Fred A., Wu, Jiaqian, Gibbs, Richard A., Weinstock, George, Wheeler, David A.
Publicado em 2004
“...Completion of the Rattus norvegicus genome sequence enabled a global inventory and analysis...”Publicado em 2004
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79
Por Heba A. S. El-Nashar, Eman M. El-labbad, Mahmood A. Al-Azzawi, Naglaa S. Ashmawy
Publicado em 2022-04-01
“...A new xanthone glycoside, 1,3,5,6-tetrahydroxyxanthone-C-4-β-<span style="font-variant: small-caps...”Publicado em 2022-04-01
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80
Por Siles, Samuel A., Srinivasan, Anand, Pierce, Christopher G., Lopez-Ribot, José L., Ramasubramanian, Anand K.
Publicado em 2013
“... active against biofilms, we have screened a small molecule library consisting of 1,200 off-patent drugs...”Publicado em 2013
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