ロード中...
Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors
IRE1 is an endoplasmic reticulum (ER) bound transmembrane bifunctional kinase and endoribonuclease protein crucial for the unfolded protein response (UPR) signaling pathway. Upon ER stress, IRE1 homodimerizes, oligomerizes and autophosphorylates resulting in endoribonuclease activity responsible for...
保存先:
| 出版年: | Sci Rep |
|---|---|
| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6399222/ https://ncbi.nlm.nih.gov/pubmed/30833722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39939-z |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|