Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

The approval of histone deacetylase inhibitors for treatment of lymphoma subtypes has positioned histone modifications as potential targets for the development of new classes of anticancer drugs. Histones also undergo phosphorylation events, and Haspin is a protein kinase the only known target of wh...

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Autors principals: Huertas, D, Soler, M, Moreto, J, Villanueva, A, Martinez, A, Vidal, A, Charlton, M, Moffat, D, Patel, S, McDermott, J, Owen, J, Brotherton, D, Krige, D, Cuthill, S, Esteller, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312407/
https://ncbi.nlm.nih.gov/pubmed/21804608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.335
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