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Computational Characterization of Small Molecules Binding to the Human XPF Active Site and Virtual Screening to Identify Potential New DNA Repair Inhibitors Targeting the ERCC1-XPF Endonuclease

The DNA excision repair protein ERCC-1-DNA repair endonuclease XPF (ERCC1-XPF) is a heterodimeric endonuclease essential for the nucleotide excision repair (NER) DNA repair pathway. Although its activity is required to maintain genome integrity in healthy cells, ERCC1-XPF can counteract the effect o...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Gentile, Francesco, Barakat, Khaled H., Tuszynski, Jack A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983712/
https://ncbi.nlm.nih.gov/pubmed/29710850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19051328
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