Resultados da pesquisa - (( ((j nav) OR (j nave)) como cande w ) OR ((( _ a2 from dat net ) OR ( j nagy clamp can new ))))

Pesquisas alternativas:
nave » naive (Expandir a Pesquisa), have (Expandir a Pesquisa), wave (Expandir a Pesquisa)
como » com (Expandir a Pesquisa)
cande » candy (Expandir a Pesquisa), pande (Expandir a Pesquisa), vande (Expandir a Pesquisa)
dat » data (Expandir a Pesquisa), date (Expandir a Pesquisa)

1

ORM-10103, a novel specific inhibitor of the Na(+)/Ca(2+) exchanger, decreases early and delayed afterdepolarizations in the canine heart

ORM-10103, a novel specific inhibitor of the Na(+)/Ca(2+) exchanger, decreases early and delayed afterdepolarizations in the canine heart

Por Jost, N, Nagy, N, Corici, C, Kohajda, Z, Horváth, A, Acsai, K, Biliczki, P, Levijoki, J, Pollesello, P, Koskelainen, T, Otsomaa, L, Tóth, A, Papp, J Gy, Varró, A, Virág, L
Publicado em 2013

“... administration of ORM-10103, a new NCX inhibitor, on the NCX and L-type Ca(2+) currents and on the formation...”
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2

How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers

How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers

Por Bhat, Shreyas, Newman, Amy Hauck, Freissmuth, Michael
Publicado no Biochem Soc Trans (2019)

“... for norepinephrine (NET/SLC6A2), dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4), have a rich pharmacology; hence...”
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3

Further Structure-Activity Relationship Studies on 8-Substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane Derivatives at Monoamine Transporters

Further Structure-Activity Relationship Studies on 8-Substituted-3-[2-(diarylmethoxyethylidenyl)]-8...

Por Cararas, Shaine A., Izenwasser, Sari, Wade, Dean, Housman, Amy, Verma, Abha, Lomenzo, Stacey A., Trudell, Mark L.
Publicado em 2011

“...)]-8-azabicyclo[3.2.1]octane derivatives were investigated at the dopamine transporter(DAT...”
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4

Synthesis and monoamine transporter binding properties of 2β-[3’-(substituted benzyl)isoxazol-5-yl]- and 2β-[3’-methyl-4’-(substituted phenyl)isoxazol-5-yl]-3β-(substituted phenyl)tropanes

Synthesis and monoamine transporter binding properties of 2β-[3’-(substituted benzyl)isoxazol-5-yl...

Por Jin, Chunyang, Navarro, Hernán A., Page, Kevin, Carroll, F. Ivy
Publicado em 2008

“... for the dopamine transporter (DAT). The IC(50) values ranged from 5.9 to 22 nM. On the other hand, the 2β-[3...”
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5

How useful and reliable are disaster databases in the context of climate and global change? A comparative case study analysis in Peru

How useful and reliable are disaster databases in the context of climate and global change? A comparative case study analysis in Peru

Por C. Huggel, A. Raissig, M. Rohrer, G. Romero, A. Diaz, N. Salzmann
Publicado em 2015-03-01

“... in the developing-country context of Peru: a global database (Emergency Events Database: EM-DAT), a multinational...”
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6

Selective activation of Dopamine D3 receptors and Norepinephrine Transporter blockade enhance sustained attention.

Selective activation of Dopamine D3 receptors and Norepinephrine Transporter blockade enhance sustained attention.

Por Marshall, Courtney A., Brodnik, Zachary D., Mortensen, Ole V., Reith, Maarten E.A., Shumsky, Jed S., Waterhouse, Barry D., España, Rodrigo A., Kortagere, Sandhya
Publicado no Neuropharmacology (2019)

“... indicate SK609 selectively inhibits NET with a K(i) value of ~500nM and behaves as a NET substrate...”
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7

Cocaine and Antidepressant-Sensitive Biogenic Amine Transporters Exist in Regulated Complexes with Protein Phosphatase 2A

Cocaine and Antidepressant-Sensitive Biogenic Amine Transporters Exist in Regulated Complexes with Protein Phosphatase 2A

Por Bauman, Andrea L., Apparsundaram, Subbu, Ramamoorthy, Sammanda, Wadzinski, Brian E., Vaughan, Roxanne A., Blakely, Randy D.
Publicado no J Neurosci (2000)

“...) transporters (DAT, NET, and SERT, respectively) are rapidly regulated by direct or receptor-mediated activation...”
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8

Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats

Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats

Por Hutsell, Blake A., Baumann, Michael H., Partilla, John S., Banks, Matthew L., Vekariya, Rakesh, Glennon, Richard A., Negus, S. Stevens
Publicado no Eur Neuropsychopharmacol (2015)

“... in potency from S(−) to R(+)4-methylcathinone was less for DAT than for SERT, and as a result, DAT vs. SERT...”
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9

Synthesis and structure-activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters

Synthesis and structure-activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine...

Por Jin, Chunyang, Navarro, Hernán A., Carroll, F. Ivy
Publicado em 2009

“... at the 5-HTT. The K(i) values ranged from 0.19 nM to 49 nM. The 3β-(4-methylthiophenyl)tropane 7a and its N...”
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10

Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine

Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine

Por Janowsky, Aaron, Tosh, Dilip K., Eshleman, Amy J., Jacobson, Kenneth A.
Publicado no J Pharmacol Exp Ther (2016)

“... identified a new class of allosteric DAT ligands, rigidified adenosine derivatives, and explored...”
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11

Risk Factor Genes in Patients with Dystonia: A Comprehensive Review

Risk Factor Genes in Patients with Dystonia: A Comprehensive Review

Por Siokas, Vasileios, Aloizou, Athina-Maria, Tsouris, Zisis, Michalopoulou, Amalia, Mentis, Alexios-Fotios A., Dardiotis, Efthimios
Publicado no Tremor Other Hyperkinet Mov (N Y) (2019)

“..., NALC, OR4X2, COL4A1, TH, DDC, DBH, MAO, COMT, DAT, GCH1, PRKRA, MR-1, SGCE, ATP1A3, TAF1, THAP1, GNAL...”
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12

Substituted methcathinones differ in transporter and receptor interactions

Substituted methcathinones differ in transporter and receptor interactions

Por Eshleman, Amy J, Wolfrum, Katherine M, Hatfield, Meagan G, Johnson, Robert A, Murphy, Kevin V, Janowsky, Aaron
Publicado em 2013

“... of preloaded [(3)H]neurotransmitter from hDAT, hSERT and hNET (highest potency at hNET), and thus...”
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13

Genetic influences on attention deficit hyperactivity disorder symptoms from age 2 to 3: A quantitative and molecular genetic investigation

Genetic influences on attention deficit hyperactivity disorder symptoms from age 2 to 3: A quantitative and molecular genetic investigation

Por Ilott, Nicholas E, Saudino, Kimberly J, Asherson, Philip
Publicado em 2010

“.... However, we also observe a significant level of genetic change from age 2 to age 3. There are modest...”
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14

Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs

Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs

Por Baumann, Michael H., Bukhari, Mohammad O., Lehner, Kurt R., Anizan, Sebastien, Rice, Kenner C., Concheiro, Marta, Huestis, Marilyn A.
Publicado no Curr Top Behav Neurosci (2017)

“... of MDPV and related analogs, and supplement the discussion with new results from our preclinical...”
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15

Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters.

Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters.

Por Aloke K Dutta, Soumava Santra, Horrick Sharma, Chandrashekhar Voshavar, Liping Xu, Omar Mabrouk, Tamara Antonio, Maarten E A Reith
Publicado em 2014-01-01

“... and 39.7 for DAT, SERT and NET, respectively) indicates a serotonin preferring triple reuptake inhibition...”
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16

LeuT-desipramine structure suggests how antidepressants inhibit human neurotransmitter transporters

LeuT-desipramine structure suggests how antidepressants inhibit human neurotransmitter transporters

Por Zhou, Zheng, Zhen, Juan, Karpowich, Nathan K., Goetz, Regina M., Law, Christopher J., Reith, Maarten E. A., Wang, Da-Neng
Publicado em 2007

“... determined the crystal structure at 2.9 Å of the bacterial leucine transporter (LeuT), a homolog of SERT, NET...”
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17

From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design

From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design

Por Yu, Li-Fang, Zhang, Han-Kun, Gunosewoyo, Hendra, Kozikowski, Alan P.
Publicado em 2012

“... for the DAT (K(i) = 373 nM) and NET (K(i) = 203 nM) in the PDSP broad screening panel of common CNS...”
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18

Detecting a potential safety signal of antidepressants and type 2 diabetes: a pharmacovigilance‐pharmacodynamic study

Detecting a potential safety signal of antidepressants and type 2 diabetes: a pharmacovigilance‐pharmacodynamic study

Por Siafis, Spyridon, Papazisis, Georgios
Publicado no Br J Clin Pharmacol (2018)

“... (SERT, NET, DAT) was estimated. The relationship between aROR for diabetes and receptor occupancy...”
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19

Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template

Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2...

Por Santra, Soumava, Sharma, Horrick, Vedachalam, Seenuvasan, Antonio, Tamara, Reith, Maarten, Dutta, Aloke
Publicado no Bioorg Med Chem (2014)

“..., respectively) or a potent DNRI profile for compounds 6b and 6h (Ki (DAT/NET); 8.94/ 4.76 and 13/ 7.37 nM...”
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20

The NH(2)-terminus of Norepinephrine Transporter Contains a Basolateral Localization Signal for Epithelial Cells

The NH(2)-terminus of Norepinephrine Transporter Contains a Basolateral Localization Signal for Epithelial Cells

Por Gu, Howard H., Wu, Xiaohong, Giros, Bruno, Caron, Marc G., Caplan, Michael J., Rudnick, Gary
Publicado em 2001

“... that the NH(2)-terminus of NET, which contains two dileucine motifs, contains a basolateral localization...”
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