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LeuT-desipramine structure suggests how antidepressants inhibit human neurotransmitter transporters
Tricyclic antidepressants exert their pharmacological effect - inhibiting the reuptake of serotonin, norepinephrine and dopamine - by directly blocking neurotransmitter transporters (SERT, NET and DAT, respectively) in the presynaptic membrane. The drug-binding site and the mechanism of this inhibit...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711652/ https://ncbi.nlm.nih.gov/pubmed/17690258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1147614 |
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