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Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures
Sertraline and fluoxetine are selective serotonin reuptake inhibitors (SSRIs) widely-prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT). All SSRIs possess at specific positions halogen atoms, which are key determinants...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758934/ https://ncbi.nlm.nih.gov/pubmed/19430461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1602 |
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