Resultados da pesquisa - (( ((drug does) OR (drug dose)) novel ther ) or ( drug ((doses devel) or (dose level)) ther ))

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Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers

Por Gu, Namyi, Park, Min Kyu, Kim, Tae-Eun, Bahng, Mi Young, Lim, Kyoung Soo, Cho, Sang-Heon, Yoon, Seo Hyun, Cho, Joo-Youn, Jang, In-Jin, Yu, Kyung-Sang
Publicado em 2014

“...PURPOSE: Evogliptin (DA-1229) is a novel, potent, and selective dipeptidyl peptidase IV (DPP-IV...”
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Early achievement and maintenance of stable asthma control using initially higher-dose inhaled...

Por Cheng, Shih-Lung, Wang, Hao-Chien, Kuo, Sow-Hsong
Publicado em 2013

“.... In this study, we attempted to increase inhaled corticosteroid (ICS) doses initially in suboptimally controlled...”
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Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Por Kuca, Kamil, Karasova, Jana Zdarova, Soukup, Ondrej, Kassa, Jiri, Novotna, Eva, Sepsova, Vendula, Horova, Anna, Pejchal, Jaroslav, Hrabinova, Martina, Vodakova, Eva, Jun, Daniel, Nepovimova, Eugenie, Valis, Martin, Musilek, Kamil
Publicado no Drug Des Devel Ther (2018)

“... of currently used drugs led to research of novel potent molecules for prophylaxis of organophosphorus...”
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A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy...

Por Shin, Wonsuk, Lim, Kyoung Soo, Kim, Min-Kyoung, Kim, Hyun Sook, Hong, Jihwa, Jhee, Stanford, Kim, Joseph, Yoo, Sungeun, Chung, Yeon-Tae, Lee, Jae Moon, Cho, Doo-Yeoun
Publicado no Drug Des Devel Ther (2019)

“... and pharmacokinetics were assessed. The starting dose was determined considering the no observed adverse effect level...”
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Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma

Por Kwak, Tae Won, Shin, Hee Jae, Jeong, Young-Il, Han, Myoung-Eun, Oh, Sae-Ock, Kim, Hyun-Jung, Kim, Do Hyung, Kang, Dae Hwan
Publicado no Drug Des Devel Ther (2015)

“... novel antineoplastic agent, in cholangiocarcinoma. METHODS: The anticancer activity of streptochlorin...”
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Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects

Por Yoon, Seonghae, Shin, Donghoon, Lee, Howard, Jang, In-Jin, Yu, Kyung-Sang
Publicado no Drug Des Devel Ther (2015)

“..., pharmacodynamics, and tolerability of the drug in healthy subjects. METHODS: A dose-block randomized, double-blind...”
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Comparison of neurotoxic potency between a novel chinbotulinumtoxinA with onabotulinumtoxinA, incobotulinumtoxinA and lanbotulinumtoxinA in rats

Por Feng, Ya, Liu, Wuchao, Pan, Lizhen, Jiang, Cong, Zhang, Chengxi, Lu, Yuxuan, Nie, Zhiyu, Jin, Lingjing
Publicado no Drug Des Devel Ther (2017)

“... to the other three products at the dose of 0.5 U. However, there was no difference between the four toxins when...”
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Effects of a novel ACE inhibitor, 3-(3-thienyl)-l-alanyl-ornithyl-proline, on endothelial vasodilation and hepatotoxicity in l-NAME-induced hypertensive rats

Por Seth, Mahesh Kumar, Hussain, M Ejaz, Pasha, Santosh, Fahim, Mohammad
Publicado no Drug Des Devel Ther (2016)

“... developed a novel sulfur-containing angiotensin-converting enzyme inhibitor: 3-(3-thienyl)-l-alanyl-ornithyl...”
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Effects of β-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within...

Por Barati, Anis, Jamshidi, Ahmad Reza, Ahmadi, Hossein, Aghazadeh, Zahra, Mirshafiey, Abbas
Publicado no Drug Des Devel Ther (2017)

“... of β-d-mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory drug (NSAID...”
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Raltegravir in the management of HIV-infected patients

Por Stellbrink, Hans-Jürgen
Publicado em 2009

“... of the compound from “boosting” of drug levels with ritonavir is an attractive feature for many patients suffering...”
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$Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa$

Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa

Por Manaf, Asman, Tjandrawinata, Raymond R, Malinda, Desi
Publicado no Drug Des Devel Ther (2016)

“...BACKGROUND: The aim of this paper is to evaluate the efficacy and safety of DLBS3233, a novel...”
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Zoledronate inhibits fibroblasts’ proliferation and activation via targeting TGF-β signaling pathway

Por Zhao, Zichang, Shen, Wei, Zhu, Hanbin, Lin, Lin, Jiang, Gening, Zhu, Yongzhe, Song, Hongyuan, Wu, Liang
Publicado no Drug Des Devel Ther (2018)

“... of fibroblasts (NIH3T3 cells), were observed. The expression of α-SMA, TGF-β1 and TGF-β2 and the level of Smad2/3...”
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Enhanced immunosuppressive effects of 3,5-bis[4(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, an α, β-unsaturated carbonyl-based compound as PLGA-b-PEG nanoparticles

Por Arshad, Laiba, Jantan, Ibrahim, Bukhari, Syed Nasir Abbas
Publicado no Drug Des Devel Ther (2019)

“...Background: 3,5-Bis[4-(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one (BBP), a novel...”
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Evaluation of ceftiofur–PHBV microparticles in rats

Por Vilos, Cristian, Constandil, Luis, Rodas, Paula I, Cantin, Mario, Zepeda, Katherine, Herrera, Natalia, Velasquez, Luis A
Publicado em 2014

“..., the development of slow release formulations presents a significant challenge, particularly in using novel...”
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Heart rate reduction for 36 months with ivabradine reduces left ventricular mass in cardiac allograft recipients: a long-term follow-up study

Por Doesch, Andreas O, Mueller, Susanne, Erbel, Christian, Gleissner, Christian A, Frankenstein, Lutz, Hardt, Stefan, Ruhparwar, Arjang, Ehlermann, Philipp, Dengler, Thomas, Katus, Hugo A
Publicado em 2013

“... in immunosuppressive drug dosage or blood levels were detected. No phosphenes were observed during 36 months...”
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Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

Por Wang, Yuren, Wallach, Jason, Duane, Stephanie, Wang, Yuan, Wu, Jianghong, Wang, Jeffrey, Adejare, Adeboye, Ma, Haiching
Publicado no Drug Des Devel Ther (2017)

“... scaffolds with HDAC inhibitory activity, we screened a drug library approved by the US Food and Drug...”
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Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents

Por Fukushima, Masakazu, Iizuka, Kenzo, Jin, Cheng, Zhang, Chun, Hong, Mei, Eshima, Kiyoshi
Publicado no Drug Des Devel Ther (2017)

“... have developed DFP-11207, a novel fluoropyrimidine, which consists of 1-ethoxymethyl-5-fluorouracil (EM...”
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Tenofovir alafenamide in the treatment of chronic hepatitis B: design, development, and place in therapy

Por Ogawa, Eiichi, Furusyo, Norihiro, Nguyen, Mindie H
Publicado no Drug Des Devel Ther (2017)

“...Tenofovir alafenamide (TAF), a novel prodrug of tenofovir (TFV), has been approved...”
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Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury

Por Wang, Yanzhe, He, Zhiyi, Deng, Shumin
Publicado no Drug Des Devel Ther (2016)

“... level of TIMP1 (P<0.01). UA exerted its protective effects in a dose-dependent manner. Co-treatment...”
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5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction

Por Keshari, Amit K, Singh, Ashok K, Kumar, Umesh, Raj, Vinit, Rai, Amit, Kumar, Pranesh, Kumar, Dinesh, Maity, Biswanath, Nath, Sneha, Prakash, Anand, Saha, Sudipta
Publicado no Drug Des Devel Ther (2017)

“... to develop novel therapeutic strategies for HCC treatment, here we investigated the in vivo antitumor...”
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