5H-benzo[h]thiazolo[2,3-b]quinazolines ameliorate NDEA-induced hepatocellular carcinogenesis in rats through IL-6 downregulation along with oxidative and metabolic stress reduction

5H-benzo[h]thiazolo[2,3-b]quinazoline scaffold is known to have an antitumor effect on certain types of malignancies; however, its effect on hepatocellular carcinoma (HCC) remains unclear. Previously, we reported p-toluenesulfonic acid-promoted syntheses, molecular modeling and in vitro antitumor ac...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Keshari, Amit K, Singh, Ashok K, Kumar, Umesh, Raj, Vinit, Rai, Amit, Kumar, Pranesh, Kumar, Dinesh, Maity, Biswanath, Nath, Sneha, Prakash, Anand, Saha, Sudipta
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648320/
https://ncbi.nlm.nih.gov/pubmed/29075102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S143075
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