Poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid for improved treatment of hepatic cancer: characterization, in vitro and in vivo evaluations

PURPOSE: The application of betulinic acid (B), a potent antineoplastic agent, is limited due to poor bioavailability, short plasma half-life and inappropriate tissue distribution. Thus, we aimed to prepare novel 50:50 poly(lactic-co-glycolic acid) (PLGA)-loaded B nanoparticles (BNP) and to compare...

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Bibliografiske detaljer
Udgivet i:Int J Nanomedicine
Main Authors: Kumar, Pranesh, Singh, Ashok K, Raj, Vinit, Rai, Amit, Keshari, Amit K, Kumar, Dinesh, Maity, Biswanath, Prakash, Anand, Maiti, Sabyasachi, Saha, Sudipta
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818879/
https://ncbi.nlm.nih.gov/pubmed/29497292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S157391
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