Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals

Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular carcinoma (HCC) specific Hep-G2 cells. Three of the synthesized compounds significantly atten...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Singh, Ashok K., Bhadauria, Archana S., Kumar, Umesh, Raj, Vinit, Rai, Amit, Kumar, Pranesh, Keshari, Amit K., Kumar, Dinesh, Maity, Biswanath, Nath, Sneha, Prakash, Anand, Saha, Sudipta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897576/
https://ncbi.nlm.nih.gov/pubmed/29651140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24288-0
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