Resultados da pesquisa - ((((drug de) OR (drug dna))v) or (((drug de) OR (drug dna)))) devel ther*

1

Changing the face of hepatitis C management – the design and development of sofosbuvir

Por Noell, Bennett C, Besur, Siddesh V, deLemos, Andrew S
Publicado no Drug Des Devel Ther (2015)

“...The availability of direct-acting antiviral (DAA) therapy has launched a new era in the management...”
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2

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Defective DNA repair mechanisms in prostate cancer: impact of olaparib

Por De Felice, Francesca, Tombolini, Vincenzo, Marampon, Francesco, Musella, Angela, Marchetti, Claudia
Publicado no Drug Des Devel Ther (2017)

“...) proteins play a key role in DNA repair mechanisms and represent a valid target for new therapies. Olaparib...”
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3

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Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii

Por de Leeuw, Erik PH
Publicado em 2014

“... compound that targets Lipid II is described that acts against multi-drug resistant isolates of A. baumannii...”
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4

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The role of taxanes in triple-negative breast cancer: literature review

Por Mustacchi, Giorgio, De Laurentiis, Michelino
Publicado no Drug Des Devel Ther (2015)

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5

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Hologram quantitative structure–activity relationship and comparative molecular field analysis studies within a series of tricyclic phthalimide HIV-1 integrase inhibitors

Por de Oliveira Magalhães, Uiaran, de Souza, Alessandra Mendonça Teles, Albuquerque, Magaly Girão, de Brito, Monique Araújo, Bello, Murilo Lamim, Cabral, Lucio Mendes, Rodrigues, Carlos Rangel
Publicado em 2013

“... immunodeficiency virus (HIV). Treatment with antiretroviral drugs is the best option for viral suppression...”
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6

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Profile of pridopidine and its potential in the treatment of Huntington disease: the evidence to date

Por Squitieri, Ferdinando, de Yebenes, Justo Garcia
Publicado no Drug Des Devel Ther (2015)

“... it might be a neuroprotective and disease-modifying drug. Data from ongoing clinical trials of pridopidine...”
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7

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Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra

Por de Farias, Pablo Antonio Maia, Figueredo, Fernando Gomes, Lucas, Aline Maria Brito, de Moura, Rafael Barbosa, Coutinho, Henrique Douglas Melo, da Silva, Tania Maria Sarmento, Martin, Ana Luiza de Aguiar Rocha, Fonteles, Marta Maria de França
Publicado no Drug Des Devel Ther (2015)

“... years, especially for new drugs with antibiotic potential. Accordingly, the aim of this study...”
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8

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Comment on a meta-analysis comparing hepatic resection or transarterial chemoembolization as initial treatment for hepatocellular carcinoma

Por Zhong, Jian-Hong, Xiang, Bang-De, Li, Le-Qun
Publicado no Drug Des Devel Ther (2015)

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9

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Aminaphtone in the control of gingival bleeding in children

Por Pereira de Godoy, José Maria, Macedo Paizan, Mara Lucia
Publicado em 2014

“... aminaphtone (Capilarema 75 mg) to fifteen patients or placebo to fifteen patients twice daily for 5 days...”
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10

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A novel small-molecule inhibitor of HIV-1 entry

Por Heredia, Alonso, Latinovic, Olga S, Barbault, Florent, de Leeuw, Erik PH
Publicado no Drug Des Devel Ther (2015)

“...BACKGROUND: Antiretroviral therapy has transformed HIV-1 infection into a managed condition...”
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11

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Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection

Por Mascellino, Maria Teresa, Porowska, Barbara, De Angelis, Massimiliano, Oliva, Alessandra
Publicado no Drug Des Devel Ther (2017)

“... regarding eradication success rates of culture-guided and empiric therapies. The empiric therapy and the one...”
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12

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Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential place in the therapy

Por Grassi, Paolo, Verzoni, Elena, Ratta, Raffaele, Mennitto, Alessia, de Braud, Filippo, Procopio, Giuseppe
Publicado no Drug Des Devel Ther (2016)

“... biological processes made this signaling pathway an attractive therapeutic target in oncology, particularly...”
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13

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Aterofisiol(®) in carotid plaque evolution

Por Amato, Bruno, Compagna, Rita, Amato, Maurizio, Gallelli, Luca, de Franciscis, Stefano, Serra, Raffaele
Publicado no Drug Des Devel Ther (2015)

“... 24 hours. Each treatment was started 30 days before the surgery and was stopped 5 days before...”
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14

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Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures [Corrigendum]

Por Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E
Publicado em 2015-12-01

“...Drug Design, Development and Therapy...”
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15

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Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis

Por Giacoppo, Sabrina, Soundara Rajan, Thangavelu, De Nicola, Gina Rosalinda, Iori, Renato, Bramanti, Placido, Mazzon, Emanuela
Publicado no Drug Des Devel Ther (2016)

“...). Released moringin (10 mg/kg glucomoringin +5 μL myrosinase/mouse) was administered daily for 1 week before...”
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16

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Effect of renal impairment on the pharmacokinetics of prucalopride: a single- dose open-label Phase I study

Por Smith, William B, Mannaert, Erik, Verhaeghe, Tom, Kerstens, René, Vandeplassche, Lieve, Van de Velde, Vera
Publicado em 2012

“... concentration–time curve from time zero to infinity values were 1.5- and 2.3-fold higher (P = 0.002 and P...”
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17

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The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

Por Serra, Raffaele, Gallelli, Luca, Conti, Angela, De Caridi, Giovanni, Massara, Mafalda, Spinelli, Francesco, Buffone, Gianluca, Caliò, Francesco Giuseppe, Amato, Bruno, Ceglia, Simona, Spaziano, Giuseppe, Scaramuzzino, Luca, Ferrarese, Alessia Giovanna, Grande, Raffaele, de Franciscis, Stefano
Publicado em 2014

“... (median age: 68.7 years) treated with standard treatment (compression therapy and surgery) + SDX (600...”
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18

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Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Por Mumoli, Laura, Palleria, Caterina, Gasparini, Sara, Citraro, Rita, Labate, Angelo, Ferlazzo, Edoardo, Gambardella, Antonio, De Sarro, Giovambattista, Russo, Emilio
Publicado no Drug Des Devel Ther (2015)

“... in the United States and the European Union as adjunctive therapy for patients with partial seizures...”
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19

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Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection

Por da Silva, Cristiane França, Batista, Denise da Gama Jaén, de Araújo, Julianna Siciliano, Cunha-Junior, Edézio Ferreira, Stephens, Chad E, Banerjee, Moloy, Farahat, Abdelbasset A, Akay, Senol, Fisher, Mary K, Boykin, David W, Soeiro, Maria de Nazaré Correia
Publicado no Drug Des Devel Ther (2017)

“... EC(50) (drug concentration that reduces 50% of the number of the treated parasites) values ranging...”
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20

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Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain

Por Plapler, Pérola Grinberg, Scheinberg, Morton Aaron, Ecclissato, Christina da Cunha, Bocchi de Oliveira, Monalisa Fernanda, Amazonas, Roberto Bleuel
Publicado no Drug Des Devel Ther (2016)

“...BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common type of medication...”
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