Raf-MEK-Erk Cascade in Anoikis Is Controlled by Rac1 and Cdc42 via Akt

Signals from the extracellular matrix are essential for the survival of many cell types. Dominant-negative mutants of two members of Rho family GTPases, Rac1 and Cdc42, mimic the loss of anchorage in primary mouse fibroblasts and are potent inducers of apoptosis. This pathway of cell death requires...

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Main Authors: Zugasti, Olivier, Rul, Wilfrid, Roux, Pierre, Peyssonnaux, Carole, Eychene, Alain, Franke, Thomas F., Fort, Philippe, Hibner, Urszula
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2001
主題:
Cell Growth and Development
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC99815/
https://ncbi.nlm.nih.gov/pubmed/11533257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.19.6706-6717.2001
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