Raf-MEK-Erk Cascade in Anoikis Is Controlled by Rac1 and Cdc42 via Akt

Signals from the extracellular matrix are essential for the survival of many cell types. Dominant-negative mutants of two members of Rho family GTPases, Rac1 and Cdc42, mimic the loss of anchorage in primary mouse fibroblasts and are potent inducers of apoptosis. This pathway of cell death requires...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Zugasti, Olivier, Rul, Wilfrid, Roux, Pierre, Peyssonnaux, Carole, Eychene, Alain, Franke, Thomas F., Fort, Philippe, Hibner, Urszula
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2001
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11533257/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.19.6706-6717.2001
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Raf-MEK-Erk Cascade in Anoikis Is Controlled by Rac1 and Cdc42 via Akt

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