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Molecular Basis for Immunoglobulin M Specificity to Epitopes in Cryptococcus neoformans Polysaccharide That Elicit Protective and Nonprotective Antibodies

The protective efficacy of antibodies (Abs) to Cryptococcus neoformans glucuronoxylomannan (GXM) is dependent on Ab fine specificity. Two clonally related immunoglobulin M monoclonal Abs (MAbs) (12A1 and 13F1) differ in fine specificity and protective efficacy, presumably due to variable (V)-region...

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Autori principali: Nakouzi, Antonio, Valadon, Philippe, Nosanchuk, Joshua, Green, Nancy, Casadevall, Arturo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC98299/
https://ncbi.nlm.nih.gov/pubmed/11292763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.3398-3409.2001
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