Molecular Basis for Immunoglobulin M Specificity to Epitopes in Cryptococcus neoformans Polysaccharide That Elicit Protective and Nonprotective Antibodies

The protective efficacy of antibodies (Abs) to Cryptococcus neoformans glucuronoxylomannan (GXM) is dependent on Ab fine specificity. Two clonally related immunoglobulin M monoclonal Abs (MAbs) (12A1 and 13F1) differ in fine specificity and protective efficacy, presumably due to variable (V)-region...

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Autores principales: Nakouzi, Antonio, Valadon, Philippe, Nosanchuk, Joshua, Green, Nancy, Casadevall, Arturo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC98299/
https://ncbi.nlm.nih.gov/pubmed/11292763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.3398-3409.2001
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