Molecular Basis for Immunoglobulin M Specificity to Epitopes in Cryptococcus neoformans Polysaccharide That Elicit Protective and Nonprotective Antibodies

The protective efficacy of antibodies (Abs) to Cryptococcus neoformans glucuronoxylomannan (GXM) is dependent on Ab fine specificity. Two clonally related immunoglobulin M monoclonal Abs (MAbs) (12A1 and 13F1) differ in fine specificity and protective efficacy, presumably due to variable (V)-region...

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書誌詳細

出版年:	Infect Immun
主要な著者:	Nakouzi, Antonio, Valadon, Philippe, Nosanchuk, Joshua, Green, Nancy, Casadevall, Arturo
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 2001
主題:	Fungal and Parasitic Infections
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11292763/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.5.3398-3409.2001
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