pH-Induced Conformational Changes in Clostridium difficile Toxin B

Toxin B from Clostridium difficile is a monoglucosylating toxin that targets substrates within the cytosol of mammalian cells. In this study, we investigated the impact of acidic pH on cytosolic entry and structural changes within toxin B. Bafilomycin A1 was used to block endosomal acidification and...

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Dades bibliogràfiques

Publicat a:	Infect Immun
Autors principals:	Qa'Dan, Maen, Spyres, Lea M., Ballard, Jimmy D.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2000
Matèries:	Molecular and Cellular Pathogenesis
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10768933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.2470-2474.2000
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