pH-Induced Conformational Changes in Clostridium difficile Toxin B

Toxin B from Clostridium difficile is a monoglucosylating toxin that targets substrates within the cytosol of mammalian cells. In this study, we investigated the impact of acidic pH on cytosolic entry and structural changes within toxin B. Bafilomycin A1 was used to block endosomal acidification and...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Qa'Dan, Maen, Spyres, Lea M., Ballard, Jimmy D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Molecular and Cellular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10768933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.2470-2474.2000
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