pH-Induced Conformational Changes in Clostridium difficile Toxin B

Toxin B from Clostridium difficile is a monoglucosylating toxin that targets substrates within the cytosol of mammalian cells. In this study, we investigated the impact of acidic pH on cytosolic entry and structural changes within toxin B. Bafilomycin A1 was used to block endosomal acidification and...

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Podrobná bibliografie

Vydáno v:	Infect Immun
Hlavní autoři:	Qa'Dan, Maen, Spyres, Lea M., Ballard, Jimmy D.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Molecular and Cellular Pathogenesis
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10768933/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.2470-2474.2000
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