Genetically Detoxified Mutants of Heat-Labile Toxin from Escherichia coli Are Able To Act as Oral Adjuvants

Detoxified mutants of the Escherichia coli heat-labile toxin (LT) act as mucosal adjuvants to intranasally presented coadministered antigens. Here, we compare the adjuvant activity of a panel of detoxified derivatives of LT, using both intranasal (i.n.) and oral (p.o.) routes of administration. The...

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Hlavní autoři: Douce, Gill, Giannelli, Valentina, Pizza, Mariagrazia, Lewis, David, Everest, Paul, Rappuoli, Rino, Dougan, Gordon
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC96758/
https://ncbi.nlm.nih.gov/pubmed/10456880
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