Genetically Detoxified Mutants of Heat-Labile Toxin from Escherichia coli Are Able To Act as Oral Adjuvants

Detoxified mutants of the Escherichia coli heat-labile toxin (LT) act as mucosal adjuvants to intranasally presented coadministered antigens. Here, we compare the adjuvant activity of a panel of detoxified derivatives of LT, using both intranasal (i.n.) and oral (p.o.) routes of administration. The...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Douce, Gill, Giannelli, Valentina, Pizza, Mariagrazia, Lewis, David, Everest, Paul, Rappuoli, Rino, Dougan, Gordon
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Microbial Immunity and Vaccines
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96758/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10456880/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.9.4400-4406.1999
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