A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.

We examined the capacity of a genetically detoxified derivative of pertussis toxin (PTX), PT-9K/129G, to act as a mucosal adjuvant for an intranasally (i.n.) administered tetanus vaccine. Groups of mice were immunized i.n. with the nontoxic C-terminal 50-kDa portion of tetanus toxin (fragment C [Frg...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Roberts, M, Bacon, A, Rappuoli, R, Pizza, M, Cropley, I, Douce, G, Dougan, G, Marinaro, M, McGhee, J, Chatfield, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173272/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7768587/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.6.2100-2108.1995
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