Mutants of Escherichia coli Heat-Labile Toxin Act as Effective Mucosal Adjuvants for Nasal Delivery of an Acellular Pertussis Vaccine: Differential Effects of the Nontoxic AB Complex and Enzyme Activity on Th1 and Th2 Cells

Mucosal delivery of vaccines is dependent on the identification of safe and effective adjuvants that can enhance the immunogenicity of protein antigens administered by nasal or oral routes. In this study we demonstrate that two mutants of Escherichia coli heat-labile toxin (LT), LTK63, which lacks A...

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Detalhes bibliográficos
Main Authors: Ryan, Elizabeth J., McNeela, Edel, Murphy, Geraldine A., Stewart, Helen, O'hagan, Derek, Pizza, Mariagrazia, Rappuoli, Rino, Mills, Kingston H. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1999
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97029/
https://ncbi.nlm.nih.gov/pubmed/10569737
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