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Intranasal Immunization with Pneumococcal Conjugate Vaccines with LT-K63, a Nontoxic Mutant of Heat-Labile Enterotoxin, as Adjuvant Rapidly Induces Protective Immunity against Lethal Pneumococcal Infections in Neonatal Mice

Immunization with pneumococcal polysaccharides (PPS) conjugated to tetanus toxoid (TT) (Pnc-TT) elicits protective immunity in an adult murine pneumococcal infection model. To assess immunogenicity and protective immunity in early life, neonatal (1 week old) and infant (3 weeks old) mice were immuni...

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書誌詳細
主要な著者: Jakobsen, Håvard, Bjarnarson, Stefania, Del Giudice, Giuseppe, Moreau, Monique, Siegrist, Claire-Anne, Jonsdottir, Ingileif
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC127807/
https://ncbi.nlm.nih.gov/pubmed/11854231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.3.1443-1452.2002
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