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Intranasal Immunization with Pneumococcal Conjugate Vaccines with LT-K63, a Nontoxic Mutant of Heat-Labile Enterotoxin, as Adjuvant Rapidly Induces Protective Immunity against Lethal Pneumococcal Infections in Neonatal Mice

Immunization with pneumococcal polysaccharides (PPS) conjugated to tetanus toxoid (TT) (Pnc-TT) elicits protective immunity in an adult murine pneumococcal infection model. To assess immunogenicity and protective immunity in early life, neonatal (1 week old) and infant (3 weeks old) mice were immuni...

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Detalhes bibliográficos
Main Authors: Jakobsen, Håvard, Bjarnarson, Stefania, Del Giudice, Giuseppe, Moreau, Monique, Siegrist, Claire-Anne, Jonsdottir, Ingileif
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127807/
https://ncbi.nlm.nih.gov/pubmed/11854231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.3.1443-1452.2002
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