Intranasal Immunization with Pneumococcal Conjugate Vaccines with LT-K63, a Nontoxic Mutant of Heat-Labile Enterotoxin, as Adjuvant Rapidly Induces Protective Immunity against Lethal Pneumococcal Infections in Neonatal Mice

Immunization with pneumococcal polysaccharides (PPS) conjugated to tetanus toxoid (TT) (Pnc-TT) elicits protective immunity in an adult murine pneumococcal infection model. To assess immunogenicity and protective immunity in early life, neonatal (1 week old) and infant (3 weeks old) mice were immuni...

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Hlavní autoři: Jakobsen, Håvard, Bjarnarson, Stefania, Del Giudice, Giuseppe, Moreau, Monique, Siegrist, Claire-Anne, Jonsdottir, Ingileif
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127807/
https://ncbi.nlm.nih.gov/pubmed/11854231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.3.1443-1452.2002
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