Mutants of Escherichia coli Heat-Labile Toxin Act as Effective Mucosal Adjuvants for Nasal Delivery of an Acellular Pertussis Vaccine: Differential Effects of the Nontoxic AB Complex and Enzyme Activity on Th1 and Th2 Cells

Mucosal delivery of vaccines is dependent on the identification of safe and effective adjuvants that can enhance the immunogenicity of protein antigens administered by nasal or oral routes. In this study we demonstrate that two mutants of Escherichia coli heat-labile toxin (LT), LTK63, which lacks A...

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Hlavní autoři: Ryan, Elizabeth J., McNeela, Edel, Murphy, Geraldine A., Stewart, Helen, O'hagan, Derek, Pizza, Mariagrazia, Rappuoli, Rino, Mills, Kingston H. G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 1999
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC97029/
https://ncbi.nlm.nih.gov/pubmed/10569737
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