Pharmacokinetic-Pharmacodynamic Modeling of Electroencephalogram Effect of Imipenem in Rats with Acute Renal Failure

The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats...

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Hlavní autoři: Dupuis, Antoine, Limosin, Anne, Paquereau, Joël, Mimoz, Olivier, Couet, William, Bouquet, Serge
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC90879/
https://ncbi.nlm.nih.gov/pubmed/11709350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3607-3609.2001
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