Pharmacokinetic-Pharmacodynamic Modeling of Electroencephalogram Effect of Imipenem in Rats with Acute Renal Failure

The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Dupuis, Antoine, Limosin, Anne, Paquereau, Joël, Mimoz, Olivier, Couet, William, Bouquet, Serge
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2001
Schlagworte:	Pharmacology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709350/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3607-3609.2001
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