Pharmacokinetic-Pharmacodynamic Modeling of Electroencephalogram Effect of Imipenem in Rats with Acute Renal Failure

The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats...

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Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Dupuis, Antoine, Limosin, Anne, Paquereau, Joël, Mimoz, Olivier, Couet, William, Bouquet, Serge
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 2001
Предметы:	Pharmacology
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709350/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3607-3609.2001
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