Pharmacokinetic-Pharmacodynamic Modeling of Electroencephalogram Effect of Imipenem in Rats with Acute Renal Failure

The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Dupuis, Antoine, Limosin, Anne, Paquereau, Joël, Mimoz, Olivier, Couet, William, Bouquet, Serge
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709350/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3607-3609.2001
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