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Population Pharmacokinetics and Use of Monte Carlo Simulation To Evaluate Currently Recommended Dosing Regimens of Ciprofloxacin in Adult Patients with Cystic Fibrosis

Pharmacodynamic data on ciprofloxacin indicate that a target area under the concentration-time curve from 0 to 24 h (AUC(0–24))/MIC ratio of ≥125 is necessary to achieve optimal bactericidal activity for the treatment of gram-negative pneumonia. The purpose of this prospective study was to (i) devel...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Montgomery, Megan J., Beringer, Paul M., Aminimanizani, Amir, Louie, Stan G., Shapiro, Bertrand J., Jelliffe, Roger, Gill, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90855/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709326/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3468-3473.2001
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